CD8A and neoplasm: Genetic ablation of Klf5, FZU00,004 (a KLF5 inhibitor) and CEL failed to reduce the frequency of tumor-infiltrating Tregs (Cd4+Cd25+Foxp3+ T cells), but Klf5 depletion increased the number of Cd3+Cd8+ T cells and increased the Cd3+Cd8+/Treg ratio (Figure 4L-N).