Furthermore, among all upregulated genes, the expression levels of ETS2, ETV4, ETV5, ETV2, ELK1, ETV3, ELF4, ELF3, EHF and ETV7 peaked in metastatic CRC, while ELF1 showed no differences between primary and metastatic CRC tissues. The gene discussed is ETS2; the disease is colorectal carcinoma.