To evaluate the roles of FGFR4 and SRC in ELF4-mediated CRC metastasis and invasion, we knocked down the FGFR4 and SRC genes in SW480-ELF4 and upregulated FGFR4 and SRC in LoVo-shELF4 (Figure 3A). The gene discussed is FGFR4; the disease is colorectal carcinoma.