Taken together, we found the FGF19-FGFR4 upregulated the expression of ELF4 via the ERK1/2/SP1 axis, and overexpression of ELF4 facilitated CRC metastasis through transactivating FGFR4 and SRC, which formed a positive feedback loop. The gene discussed is SRC; the disease is colorectal carcinoma.