In Helicobacter pylori-mediated gastric cancer, the FGF19/FGFR4 axis increased the level of STAT3, while elevated STAT3 could promote the transcription of FGFR4 and form the FGF19-STAT3-FGFR4 positive feedforward loop 51. This evidence concerns the gene FGFR4 and gastric cancer.