ABCA1 and atherosclerosis: Our study showed that GLSP can reduce lipid deposition in macrophage-derived foam cells, and then we examined the gene expression levels related to lipid production, consumption, and efflux, and found that GLSP can reduce lipid synthesis and increase lipid efflux, which mainly improves ABCA1/G1-mediated cholesterol efflux and further reducing atherosclerosis.