MDM2 and breast cancer: Several compounds capable of direct MDM2 binding to induce its downregulation or degradation include JapA 71, Inulanolide A, and lineariifolianoid A. These compounds not only induce MDM2 protein degradation and represses its transcription, the latter two also inhibit NFAT1, an MDM2 transactivator frequently overexpressed in breast cancer 72, 73.