Examples of stapled peptides that have been evaluated in breast cancer models include SAH-p53-8 which exhibited better response in MCF-7 compared to Nutlin-3 69 and ATSP-7041 which was reported to induce a prolonged inhibitory effect of MDM2-p53 interaction in MCF-7 with favorable pharmacokinetic properties 70. The gene discussed is MDM2; the disease is breast cancer.