TP53 and breast cancer: Several of these include c-MYC, MAP2K3, CXCL1, and CCNE2. Moreover, mutant p53 has been reported to interact with several proteins or transcription factors that drive breast cancer proliferation such as the sterol regulatory element-binding protein (SREBPs) via activation of mevalonate pathway 32, PARP 33, NF-Y 34, and DAB2IP 35.