While most of these combinations have not been evaluated in breast cancers, the consensus from these studies is that these various combinations resulted in 1) increased immune response such as cytotoxic T cell activities and CD8+ T cell infiltration, 2) a reduction in immunosuppressive cells (M2 macrophages) and expression of immunosuppressive regulators, and 3) have the potential to reverse resistance to ICIs. Here, CD8A is linked to breast cancer.