The tumor microenvironment of the chromothripsis group was significantly less sensitive to ICB treatment than that of the non-chromothripsis group (POPLAR signature, median 3.63 × 10-1 vs 3.17 × 10-1, P = 1.4 × 10-3; Checkmate 275 signature, median 4.40 × 10-1 vs 4.11 × 10-1, P = 3.2 × 10-3; IFN-γ-related signature, median 4.51 × 10-1 vs 4.34 × 10-1, P = 8.7 × 10-4; IMvigor210 signature, median 3.66 × 10-1 vs 2.70 × 10-1, P = 5.1 × 10-9; Figure 2F), which is consistent with the results obtained from TCGA dataset. Here, IFNG is linked to neoplasm.