From patient samples, we obtained the mutation frequencies in ICB-responsiveness-related genes (including TP53, KRAS33, PTEN34, JAK1/2 35, and B2M36), the tumor mutation burden (TMB) 37, 38, the burden of somatic copy number alterations 19, and the level of somatic copy-number alterations (quantified as weighted genome instability (wGII) 39; see Materials and Methods for details) to comprehensively compare their relationship with chromothripsis. The gene discussed is TP53; the disease is neoplasm.