GPT2 and breast carcinoma: Furthermore, the wound healing assay, transwell evaluation, and invasion test showed that GPT2 overexpression significantly promoted migration and invasion of breast cancer BT549 cells (Figures 1E, 1F & S1C); in contrast, depletion of GPT2 inhibited migration and invasion of breast cancer BT549 cells (Figures 1G, 1H & S1D).