DICER1 and acute myeloid leukemia: However, significant expression alterations were detected in AML patients across various sncRNAs, such as cyto-5'tsRNAGly, cyto-inner'tsRNALeu, cyto-5'tsRNALys, cyto-5'tsRNACys, ysRNARNY4, and ysRNARNY5, indicating that serum sncRNAs have experienced reshaping due to the activities of cleavage enzymes (e.g., ANG, Dicer, RNaseZ, and RNaseP) and the modifications they harbor (e.g., m7G, m6A, m5C).