However, significant expression alterations were detected in AML patients across various sncRNAs, such as cyto-5'tsRNAGly, cyto-inner'tsRNALeu, cyto-5'tsRNALys, cyto-5'tsRNACys, ysRNARNY4, and ysRNARNY5, indicating that serum sncRNAs have experienced reshaping due to the activities of cleavage enzymes (e.g., ANG, Dicer, RNaseZ, and RNaseP) and the modifications they harbor (e.g., m7G, m6A, m5C). The gene discussed is ELAC1; the disease is acute myeloid leukemia.