It has been shown that HSP90B1 is regulated by Mir-99a-3p to participate in the pathogenesis of head-neck cancer (Okada et al., 2019), and the highly expressed HSP90B1 represents the poor prognosis of many tumors, including breast cancer and lung cancer (Lin et al., 2020; Liu et al., 2019). Here, HSP90B1 is linked to head and neck cancer.