For example, curcumin combined with a chemotherapy medicine, paclitaxel have a potential to inhibit MDA-MB-231 and MCF-7 breast cancer cell growth and induce the apoptosis signaling pathway through upregulating Caspase-3, Caspase-8, BAX, p53, oxidative stress (Kang et al., 2009; Quispe-Soto & Calaf, 2016; Zhan et al., 2014; Zhang et al., 2020). Here, CASP8 is linked to breast carcinoma.