The interaction between menthol and proposed associated proteins (Caspase-3, BAX, p53, MDM2, ATG3 and mTOR) revealed that many targets involved in the response to menthol, including RICTOR, RRTOR, MLST8, RPS6KB1 and AKT1, which play a role in mTOR signaling pathway, have reported their overexpression in several cancer cells such as breast, lung, colon cancer cells. Here, MDM2 is linked to malignant colon neoplasm.