Menthol increases mitochondrial membrane depolarization through TRPM8 channel leading to cell death in human bladder cancer T24 cells (Li et al., 2009b) and enhances anti-tumor effects by downregulating cytochrome P450 3A4 (CYP3A4) in human hepatocellular carcinoma HepG2 cells (Nagai et al., 2019). The gene discussed is CYP3A4; the disease is urinary bladder carcinoma.