TARDBP and Alzheimer disease: Our studies demonstrate the development of AD, PD, and TDP-43 pathology starting in childhood, and it is corroborated clinically with the progressive cognitive deterioration, abnormal gait and equilibrium, brainstem-evoked auditory potentials, olfactory deficits, sleep abnormalities, and brain MRI cortical, subcortical, and cerebellar atrophy in seemingly healthy individuals (36–42).