The mostcommon EBS subtypes observed in clinical practice arecaused by mutations in the keratin 5 or 14 genes (70–80 % ofcases), while according to the literature data, at least 17 % ofpatients with EBS had mutations de novo (Bolling et al., 2011;Wertheim-Tysarowska et al., 2016). Here, KRT5 is linked to epidermolysis bullosa simplex.