A special phenotype, laryngo-onycho-cutaneous syndrome(LOC syndrome), manifests pathogenic variants that forma stop codon in exon 39, specific for the alpha-3 subunit ofthe LAMA3 gene, where three causative variants have beendescribed so far: p.V51fs; p.Gln157Ter; p.Trp16Ter (Wanget al., 2022). Here, LAMA3 is linked to LOC syndrome.