Mild manifestations of EB are caused by missense mutations,splicing site mutations, and deletions with preservationof the reading frame, which, leading to a change in the keypositions of protein subunits, affect the ability of laminin α3,β3, and γ2 to assemble into a trimeric molecule, its secondarystructure, and its ability to form intracellular anchor fibrils(Kiritsi et al., 2011). This evidence concerns the gene LAMA3 and epidermolysis bullosa.