KRT5 and epidermolysis bullosa simplex: In thelocalized EBS subtype, pathogenic variants are clustered inboth KRT5 and KRT14, usually outside the highly conservedcore domain boundary motifs, as well as in L12 linkers, inaddition, in the KRT5 gene in the H1 domain, causing structuralinstability of the filaments (Bardhan et al., 2020).