In this regard, in HCV-induced HCC, attention shouldalso be paid to hypomethylated loci, which, as shown inthis study, belong to GPCR proteins (CCL20, GPR109A andGRM8), localized in the binding sites of such TFs as HOX(ADAMDEC1), ZNF (CD79A, MLH1) or in the region ofserine protease inhibitor genes, one of which – SPINK1 – iscurrently considered as a marker capable of detecting HCCof viral etiology at an early stage. Here, SPINK1 is linked to hepatocellular carcinoma.