The deficit can leadto the occurrence of cutaneous or hypodermal hemorrhages,as well as the development of trophoblast with abnormal vascularstructure at later stages of gestation (Arai et al., 2003).CUL7 mutations in the embryo line are associated with the3-M syndrome, which is characterized by pre- and postnatalgrowth retardation (Maksimova et al., 2007; Fu et al., 2010). This evidence concerns the gene CUL7 and multiple congenital anomalies-hypotonia-seizures syndrome 3.