JAG1 exists as an essential Notch ligand that triggers Notch signaling through cell-cell interactions to promote tumor growth and has been reported to correlate with a poor clinical prognosis in multiple carcinomas, such as hepatocellular carcinoma (37), gastric carcinoma (38), breast carcinoma (39), ovarian carcinoma (40). The gene discussed is JAG1; the disease is gastric carcinoma.