Furthermore, although the univariate analysis showed that the inflammation-related indicators leukocytes, neutrophils, lymphocytes, and CRP and the liver injury-related indicators albumin, ALT, AST, γ-GT, ChE, and ALP were significantly different between GBC and GS patients, these indicators were not included in the multivariate analysis because the significance of these indicators in tumor diagnosis was not definite and their increase may be caused by tumor-necrotizing inflammation caused by GBC itself or liver tissue damage around the gallbladder. This evidence concerns the gene CRP and neoplasm.