These results suggested that when two or more of the five indicators, namely, age (≤58.5 vs. >58.5 years), size of gallstones (≤1.95 vs. >1.95 cm), course of gallstones (≤10 vs. >10 years), CEA (≤5 vs. >5 ng/ml), and CA199 (≤37 vs. >37 U/ml), were positive, or when the nomogram score was greater than 82.64, the risk of GBC in patients with gallstones was significantly increased. Here, CEACAM5 is linked to gallstones.