Although the immunopathogenesis of IIM is not completely understood, previous studies have shown the overexpression of proinflammatory cytokines like IL-1α, IL-1β, TNF-α (Reviewed in 35), IL-18 and type I and II IFN (36) in peripheral blood and muscle of patients with this group of diseases. Here, IL18 is linked to acquired idiopathic inflammatory myopathy.