In this investigation, we screened for differential expression circRNAs in plasma of healthy individuals, pneumonia patients without sepsis, and pneumonia-induced sepsis patients using RNA-seq and recognized the significantly downregulated circRNA, circ_0075723, which is generated from the exons of gene NUP153. We also showed that circ_0075723 acted as a negative regulator of macrophage pyroptosis and inflammatory damage in pneumonia-induced sepsis, in addition to the pathways associated with miR-155-5p and SHIP1. Here, NUP153 is linked to pneumonia.