Firstly, we found that CD14+ monocytes from pneumonia-induced sepsis patients had considerably greater levels of the proteins TLR4, NLRP3, ASC1, cleaved caspase-1, IL-1, and GSDMD in contrast to pneumonia patients without sepsis and healthy people (Figure 3A, Supplementary Figure 3A). Here, CASP1 is linked to pneumonia.