To further explore the mechanisms responsible for the discordance in methylation levels in various cancers, we assessed the correlation between FAM110A and four methyltransferase genes, named DNA methyltransferase 1 (DNMT1), DNMT2, DNMT3A, and DNMT3B, and found a significant correlation between them and FAM110A in STAD, KICH, KIRC, KIRP, and LIHC (Figure 3C). Here, TRDMT1 is linked to cancer.