IL2 and pancreatic neoplasm: Recently, we created a new pancreatic cancer xenograft model using IL2RG gene knockout Syrian hamsters (named ZZU001) with IL-2, IL-4, IL-7, IL-9, IL-15, and IL- 21 receptor function deficiencies, resulting in a significantly decrease in T lymphocyte activity and non-functional B and NK cells, producing a severely immunocompromised state (8, 11).