PTGS2 and non-small cell lung carcinoma: Histopathologically, it shows a subtype of adenocarcinoma, which is very similar to the type of adenocarcinoma of human non-small cell lung cancer (NSCLC), and the common feature with human lung cancer is that tumor tissues overexpress cyclooxygenase-2 (COX-2) and nuclear factor kappa B (NF-kappaB), which are important factors in the pathogenesis of lung cancer (44).