Tumor-associated neutrophils (TANs) display two typical phenotypes of polarization, which can switch into one another during tumor progression: the anti-tumoral N1 polarization elicited mainly by IFN-β and the protumoral N2 polarization induced by G-CSF, TGF-β1, and IL-6 (86). This evidence concerns the gene TGFB1 and neoplasm.