The Gal-3 level was an independent predictor of invasive mechanical ventilation and/or in-hospital mortality in COVID-19 patients (41.17 [29.71-52.25] vs. 23.76 [15.78-33.97] ng/mL) with an OR of 3.68 [1.47-9.20] in a forward-stepwise logistic regression model (P<0.01). Here, LGALS3 is linked to COVID-19.