COVID-19 patients had insignificant levels of Gal-3 compared to controls (9.3 [7.1-12.3] vs. 8.5 [6.9-10.8]; P = 0.10). In addition, in COVID-19 patients, higher levels of Gal-3 had detected in patients admitted to ICU or patients dead at 30 days (12.1 [10.3-15.9] ng/mL vs. 8.1 [6.5-11.3] ng/mL; P<0.001). The gene discussed is LGALS3; the disease is COVID-19.