Gal-3 levels were significantly higher in severe COVID-19 patients compared to non-severe ones (1.07 ± 0.75 vs. 0.484 ± 0.317; P<0.0001). High Gal-3 level was also associated with higher in-hospital mortality, need for advanced ventilatory support, and need for ICU admission. Here, LGALS3 is linked to COVID-19.