No significant difference was seen in serum Gal-3 levels in COVID-19 patients compared with healthy controls (P>0.05). However, patients with pneumonia had significantly higher levels compared to healthy controls (P=0.009). A positive correlation was detected between Gal-3 levels and length of hospital stay (R=0.28; P=0.023). Gal-3 above 13.51 ng/mL was associated with pneumonia with 52% sensitivity and 86% specificity. The gene discussed is LGALS3; the disease is susceptibility to pneumonia measurement.