SIRT1 and cancer: Quercetin 3,5,7,3′,4′-pentamethyl ether (KPMF-8), a natural STAC (sirtuin-activating compound) from KP, directly interacts with SIRT1 (Sirtuin1, a NAD + -dependent deacetylase, is an essential regulator that produces multiple physiological benefits, such as the prevention of cancer and age-related diseases) and stimulates SIRT1 activity by increasing SIRT1’s binding affinity with Ac-p53 peptide, a native substrate peptide.