Kaempferol, a flavonoid that is abundant in the KR inhibits the MAPK pathway prevented rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) from migrating, invading, and expressing matrix metalloproteinases (MMPs), which markedly reduced the production of tumour necrosis factor (TNF-). The gene discussed is TNF; the disease is rheumatoid arthritis.