Shimada et al. (2011) found that pancreatic lipase is strongly inhibited by ethyl acetate extract of KP and its component PMFs (polymethoxyflavones), which may help to prevent obesity and other metabolic diseases. Hidaka et al. (2017), used TSOD mice as an obesity model in their study and found that PMFs reduced the buildup of the subcutaneous fat layer. The gene discussed is PNLIP; the disease is obesity due to melanocortin 4 receptor deficiency.