The present findings suggest the CC genotype of ABCC4-rs3742106 is associated with decreased concentrations of AT and its metabolites, whereas patients carrying the ABCC4-rs868853 or NR1I2-rs6785049 variant had higher concentrations of 2-AT+2-ATL in plasma compared with homozygous wild-type carriers with CKD. This evidence concerns the gene ABCC4 and chronic kidney disease.