REN and atherosclerosis: In all of them, AGE-RAGE signaling pathway in diabetic complications (hsa04933) exhibited the most significant enrichment, following by fluid shear stress and atherosclerosis (hsa05418), renin-angiotensin system (hsa04614), rheumatoid arthritis (hsa05323), diabetic cardiomyopathy (hsa05415) and HIF-1 signaling pathway (hsa04066).