GNRH1 and epilepsy: Gonadotropin-releasing hormone neurons are the central output pathway in the neural control of the HPG axis and are likely mediators of epilepsy-associated reproductive dysfunction.4 Previous work in TLE mouse models found altered activity of GnRH neurons to be associated with reproductive disruption in the form of prolonged estrous cycles.5 Importantly, estrous stage had a differential effect on GnRH activity in irregularly cycling mice; GnRH neurons were hyperexcitable in diestrus and hypoexcitable, or silent, on estrous.