In addition, inactivated CD4+ T cells (CD4+CD3+CD45+PD-1−Foxp3−) and activated CD4+ T cells (CD4+CD3+CD45+PD-1+) were in higher abundance in CA patients, suggesting a stronger CD4 T-cell response and a higher potential of incoming CD4 T-cell response in CA patients. Here, CD4 is linked to cancer.