KCNJ10 and Alkalosis: Therefore, we speculate that whether the KCNJ16 mutant shows metabolic acidosis or metabolic alkalosis depends on whether the effect of the mutant on Kir4.2/5.1 and Kir4.2 in the proximal tubule is dominant or the effect on Kir4.1/5.1 and Kir4.1 in the distal tubule is dominant (Schlingmann et al., 2021).