In a 2022 study, RNA transcriptome profiles and clinical data analysis of patients with clear cell renal cell carcinoma (ccRCC) showed that KCNJ16 expression was downregulated in patients with ccRCC, which was believed to be closely related to biological activities such as transmembrane transport and cell structure maintenance. Here, KCNJ16 is linked to nonpapillary renal cell carcinoma.