Therefore, the occurrence of hypokalemia in mice with Kir5.1 dysfunction may be related to the widespread distribution of Kir5.1 in renal tubules; Kir4.2/5.1 is expressed in the basolateral membrane of proximal tubular epithelial cells, and Kir4.1/5.1 is expressed in the basolateral membrane of TAL and DCT epithelial cells and CCD principal cells. The gene discussed is KCNJ10; the disease is Hypokalemia.