NF1 and plexiform neurofibroma: He was diagnosed with NF1 at the age of 2 years for the presence of Cafè-au-lait macules and genetic testing confirmed the diagnosis through the detection of the de novo NF1 (NM_000267.3): c.6179T > G (p.Leu2060*) pathogenic variant in the NF1. After the identification of multiple inoperable plexiform neurofibromas of the spine, treatment with Selumetinib was started at the dose of 25 mg/m2 orally 2 times a day when the patient was 4 years old.