Zimmer (Zimmer et al., 2008) reported a small molecule inhibitor of HIF-2α, C76, facilitates the binding of Iron Regulatory Protein 1 (IRP1) to the IRE of EPAS1 message and abolishes EPAS1 translation, showing as a potential strategy ameliorating the vascular remodeling and right ventricular hypertrophy in PH. Here, ACO1 is linked to Right ventricular hypertrophy.