EPAS1 and steatosis: In addition to glycolysis, accumulated HIF-2α during chronic hypoxia impairs fatty acid β-oxidation in hepatocytes and ultimately leads to steatosis by suppressing the expression of carnitine palmitoyl transferase 1 (CPT-1) and proliferator-activated receptor-γ coactivator-1α (PGC-1α), rate-limiting enzymes for the β-oxidation pathway, which can be rescued after EPAS1 knockdown (Liu et al., 2014).