Toshiharu Y (Yamashita et al., 2008) illustrated, however, that HIF-2α governs erythropoiesis by specifically regulating vascular adhesion molecule-1(VCAM-1) expression in ECs to maintain the hematopoietic microenvironment compared to normocytic anemia in mice with EPAS1 knockdown. This evidence concerns the gene EPAS1 and anemia (phenotype).