WP1066, the most rapidly investigated STAT3 inhibitor, can inhibit STAT3 phosphorylation by blocking GBM cell proliferation and induction of apoptosis in GBM cells (Iwamaru et al., 2007; Guo et al., 2012), and by inhibiting STAT3 can significantly improve the sensitivity of GBM to radiotherapy. The gene discussed is STAT3; the disease is glioblastoma.