IL-6/JAK2/STAT3 activation is mediated by the upregulation of EMT-induced transcription factors (e.g., Snail Zeb1, JUNB and Twist-1) to induce EMT, together with enhancing tumor cell migration and motility by activating the adherent patch kinase (FAK) (Jin, 2020). The gene discussed is STAT3; the disease is neoplasm.