EGFR and glioblastoma: Several factors have been reported to be associated with the activation of STAT3 in GBM, including positive regulator (e.g., BMX), and downstream cytokines of the STAT3 signaling pathway [e.g., growth factor receptor (EGFR), platelet growth factor (PDGF), c-Met, and Suppressor of cytokine signaling (SOCS)].