In glioma cell line U87 treated with 30 μm EGCG, it was observed that EGCG effectively reduced WT-MT1-MMP-mediated Src and STAT3 phosphorylation, upregulated glioma cell apoptosis and inhibited neurosphere formation in glioma cells (Djediai et al., 2021). Here, STAT3 is linked to central nervous system cancer.