After adjustment for age and sex, factor 3 (Tyr, Leu, Val, Met, Trp, Phe, Thr), factor 7 (C0, C3, C4), factor 8 (Gly, Ser), factor 9 (Ala, Pro, C4DC), factor 10 (Glu, Asp, C18:2OH), factor 11 (citrulline, ornithine) and 13 (C18OH, C18:1 OH) were independently correlated with metabolic syndrome. The gene discussed is F9; the disease is metabolic syndrome.