TG and legionellosis: Three significant enrichment pathways in terms of metabolism are glycan biosynthesis and metabolism, metabolism of cofactors, glycan biosynthesis and metabolism; thyroid hormone synthesis, ovarian steroidogenesis, and regulation of lipolysis in adipocytes were enriched in organismal systems; MAPK signaling pathway, cAMP signaling pathway and Hippo signaling pathway found in environmental information processing; endocrine resistance, malaria, legionellosis classed in human diseases (Figures 4C,D).