In the future, we will study the gene matrix of DM complicated with AD, and look for the marker genes of this process (perhaps the key genes ADCY5, PTGS2, RAB10, etc. that we have studied play a role in this dynamic process), thereby effectively controlling the development of DM symptoms; Thirdly, the function of hub genes in disease needs further verification by corresponding biological models. This evidence concerns the gene ADCY5 and Alzheimer disease.