Our study found that the top three most positive important variables for AD classification were PRKACG, RAPGEF3, and LRRK2. Three negative weights, such as EEA1, RAB14, and NF1. The top three most positive variables for DM classification were PRKACG, RAPGEF3, and RAB14. This evidence concerns the gene LRRK2 and Alzheimer disease.