Besides, we also use the Attie lab diabetes database (the interactive database of gene expression and diabetes-related clinical phenotypes, http://diabetes.wisc.edu/correl_f2.php) and found that ADCY5 and SOS1 had a significant positive association with insulin and body weight, but significantly negatively associated with glucose; On the contrary, PTGS2, EEA1 were significantly and positively associated with glucose, but a significant negative association with insulin and body weight. This evidence concerns the gene SOS1 and diabetes mellitus.