CXCL8 and ulcer disease: Furthermore, ulcers and gastric cancer appear most frequently when the infectious strain expresses CagA (cytotoxic-associated protein) and VacA (vacuolating toxin) genes, secondary to an important inflammatory and immune response, mainly associated with the synthesis of interleukin 8 (IL-8), a significant mediator of gastric inflammation (Tshibangu-Kabamba and Yamaoka, 2021).