We showed that, in coculture with human PBMCs, control RNF43-mutant HPAF-II pancreatic adenocarcinoma cells inhibit the stimulation of GMCSF and IFNγ production as well as CD4 and CD8 T-cell proliferation, effects that were reversed by preincubation of the HPAF-II cells with RXC004. Here, CD4 is linked to pancreatic adenocarcinoma.