We confirmed anti-PD-1 treatment had no effect on tumor volume, whereas significant tumor growth inhibition versus control animals was seen in response to RXC004 as either a monotherapy or in combination with anti-PD-1 (Fig. 5A and B, bodyweight data for the SNU1411 model and the B16F10 models are shown in Supplementary Fig. S5A and S5B). The gene discussed is PDCD1; the disease is neoplasm.