A reduction of BDNF level in the serum of DM1 patients has been reported previously [18], but the level of BDNF and the integrity of BDNF signaling in DM1 brains have not been established nor is it known if BDNF supplementation may improve the synaptic activity of DM1 neurons. The gene discussed is BDNF; the disease is myotonic dystrophy type 1.