In the binary logistic regression analysis, we suggested that serum osteocalcin levels were associated with multiple cardiovascular risk factors according to age and sex, including overweight/obesity, high HbA1C, high FBG, high TG, MetS, and LDL-C, after adjusting for potential confounding variables. The gene discussed is BGLAP; the disease is obesity due to melanocortin 4 receptor deficiency.