Moreover, Western blot showed that compared with the NC group, FOXK2-142aa expression was reduced, and knockdown of circFOXK2 significantly decreased LDHA phosphorylation at Tyr10 in the tumor tissues while suppressing circFOXK2 and upregulating FOXK2-142aa expression could restore the phosphorylation levels (Fig. 5G). This evidence concerns the gene LDHA and neoplasm.