It was found that transfection with the circFOXK2 or FOXK2-142aa vector significantly enhanced the phosphorylation at the Tyr10 site of LDHA, unlike the empty vector and circFOXK2-mut, suggesting that FOXK2-142aa interacted with LDHA to activate its Tyr10 (phosphorylation) in HCC cells (Supplemental Fig. 3B). The gene discussed is LDHA; the disease is hepatocellular carcinoma.