For allergic models and AD, intracerebral injection of interleukin-4/13 ameliorates cognitive deficits in AD mice by inhibiting Aβ accumulation through increased Aβ clearance by M2-like activation of microglia [33]. Microglia treated with interleukin-4 may play a protective role against AD by increasing the uptake and degradation of Aβ in a process partially mediated by autophagy [34]. The gene discussed is IL4; the disease is Alzheimer disease.