Our insights into DSS-induced colitis and Aβ accumulation are supported by a recent study that showed that DSS can induce a moderate colitis in AppNL-G-F mice, resulting in increased Aβ accumulation with decreased microglial motility and phagocytosis [14]. Since our acute colitis model did not confirm the decreased CD68 expression shown by Sohrabi et al [14], different mechanisms may be involved rather than the phagocytic capacity of microglia. Here, CD68 is linked to colitis.