Apart from the “Total 17 NAbs” cluster, the NAb clusters for “Alzheimer’s disease” (SORL1, ADAM10, CLU and TREM2) and “Neurodegenerative disease” (SORL1, ADAM10, CLU and TREM2 and WWOX) showed the best diagnostic performance for AD with sensitivity (against 95% specificity) up to 0.759. Here, TREM2 is linked to early-onset autosomal dominant Alzheimer disease.