SPRED2 and Alzheimer disease: In addition, although some novel NAbs target proteins and risk genes (NDUFAF6, OARD1, SLC24A4, SPPL2A, ADAMTS4, SPRED2, TMEM163, TSPAN14, VKORC1, and others) are reported to be associated with AD in GWAS [5, 6], the mechanisms underlying AD pathogenesis are unclear.