However, the inhibition of FASN by C75 markedly attenuated lung endothelial barrier collapse in obese mice with LPS-induced ALI, which was determined by decreases in EBD contents in lungs (Fig. 10b), lung W/D ratio (Fig. 10c), total protein levels in BALF (Fig. 10d), and inflammatory cytokines in the lungs (Fig. 10e–g). Here, FASN is linked to acute respiratory distress syndrome.