Crucially, the STMN2 cryptic exon was confirmed to be detectable also in ALS-FTD brains and spinal cords where TDP-43 pathology is present and specifically in patient post-mortem neurons with TDP-43 pathology isolated by laser capture or nuclear sorting [30–32, 37]. This evidence concerns the gene STMN2 and amyotrophic lateral sclerosis.