The Chinese diagnostic criteria employ two major components for the diagnosis of NAFLD: (i) liver imaging study meeting diffuse fatty liver criteria and not explained by any other causes; (ii) individuals with components of metabolic syndrome with continuous elevation of ALT or AST and GGT or both from an unknown cause for more than 6 months; and finally, if abnormal fatty liver imaging or zymogram shows improvement after weight reduction and improvement of insulin resistance occurs, the diagnosis of NAFLD is definite. The gene discussed is GPT; the disease is Insulin resistance.