Three coding variants associated with atherosclerosis with genome-wide significance were identified in Case 1: rs28846866 in ATXN2L, rs113300001 in POLR1B, and rs56236602 in MMP19. Two reference single-nucleotide polymorphism variants (rs54417522 in BMP4, rs9887388 in TXNDC2) reported to be associated with atherosclerosis were found in Case 2. This evidence concerns the gene POLR1B and atherosclerosis.