COL6A1 and aortic aneurysm: Defects in the components of those pathways [Collagen Type IV Alpha 2 Chain (COL4A2), Collagen Type IV Alpha 1 Chain (COL4A1), Collagen Type VI Alpha 1 Chain (COL6A), Elastin (ELN)] were previously proposed to be associated with aortic aneurysm formation [33].