Defects in the components of those pathways [Collagen Type IV Alpha 2 Chain (COL4A2), Collagen Type IV Alpha 1 Chain (COL4A1), Collagen Type VI Alpha 1 Chain (COL6A), Elastin (ELN)] were previously proposed to be associated with aortic aneurysm formation [33]. Here, COL4A1 is linked to aortic aneurysm.