Specifically, a stronger association between ALB and the renal prognosis was observed in patients with nephrosclerosis (HR = 0.23, 95%CI:0.12–0.44) and glomerulonephritis (HR = 0.52, 95%CI:0.21–1.25) as etiologies of CKD, but was attenuated in patients with diabetic nephropathy (HR = 0.86,95%CI:0.56–1.32). The gene discussed is ALB; the disease is chronic kidney disease.