The multivariable-adjusted Cox proportional hazards models and linear regression models showed a negative association between ALB and renal prognosis (HR = 0.61, 95%CI: 0.45–0.81, P < 0.001) and renal function decline (β = -1.41, 95%CI: -2.11 to -0.72, P < 0.001) in the present study after adjusting hypertension, age, diabetes, Hb, gender, BMI, use of CCB, history of CVD, UPCR, SBP, urinary occult blood, eGFR, use of RAAS inhibitor, and use of diuretics. Here, GSTM1 is linked to diabetes mellitus.