AQP4 and brain injury: In acute brain injury mice model, AQP4 knockout shows a reduction in inflammatory response and a decreased activation of astrocytes.[67] Similarly, data from our results suggest also that deficiency of AQP4 inhibits astrocyte‐induced inflammation, restoring astrocyte autophagy function and also autophagy inhibitor 3‐MA can counteract the effect of AQP4 deficiency.