AQP4 and Sepsis: Electroencephalogram (EEG) recordings with abnormal findings represent a mental dysfunction in sepsis and it may show an increased delta and decreased alpha activity even if the neurological signs are normal.[52, 53] Certain reports have shown that in septic patients, the EEG data showed progressive slowing of brain activity with the increasing severity of SAE.[34] AQP4 knockout revised the increase of delta and decrease of alpha wave activity in septic mice in our experiment.