Astrocytes secrete pro‐inflammatory factors that can induce and/or regulate inflammatory response magnitude and outcome, thus controlling neuroinflammation in sepsis.[39, 40] We investigated the effects of AQP4 on the CLP‐induced astrocyte responses especially to observe its activation, therefore western blot and immunofluorescence staining were done. The gene discussed is AQP4; the disease is Sepsis.