Postsynaptic protein NMDA receptors (NR2B) and postsynaptic density 95 (PSD95) are proteins related to synaptic plasticity.[37, 38] Thus, we detected the expression level of NR2B and PSD95 in cortex and hippocampus to evaluate cognitive impairment of mice. The gene discussed is GRIN2B; the disease is Cognitive impairment.