Il10‐knockout (Il10−/−) mice develop spontaneous colitis by 2–4 months of age.[15] To further validate this phenotype, we crossed Ythdc1f/f or mYthdc1−/− mice with Il10−/− mice to detect the roles of YTHDC1 in a spontaneous colitis model. The gene discussed is YTHDC1; the disease is colitis.