Recently, pioneering research has suggested the communication between gut microbiota and macrophages is important for maintaining intestinal homeostasis.[29] Particular attentions are now focusing on microbiota‐produced metabolites, believed to have immunomodulatory abilities to manipulate macrophage plasticity.[29] Here, we reported that microbiotas from IBD patients or mice are capable of decreasing YTHDC1 expression in intestinal‐resident macrophages. Here, YTHDC1 is linked to inflammatory bowel disease.