YTHDC1 is well known as a reader recognizing m6A modification on RNAs via the YTH domain.[1b] To determine whether YTHDC1 in macrophages prevents colitis dependent on m6A RNA methylation, we constructed two identified YTH m6A‐binding‐site mutants[6a] of YTHDC1 (W378A and W429A) and transduced them into Ythdc1‐depleted BMDMs with validation (Figure S5a). The gene discussed is YTHDC1; the disease is colitis.