NME1 and colon carcinoma: NME1, which showed robust decreases in the macrophages and colonic epithelial cells from diseased tissues (Figure 5k,l; Figures S6n,o and S7c,d, Supporting Information), is identified to be required for maintaining the adherens junctions of colon carcinoma cells.[21] Recently, NME1 is reported to be a member of the macrophage secretomes that are secreted to exert biological actions outside of macrophages.[22] Thus, we reasoned that macrophage‐produced NME1 might be a main source compensating for the loss of that secreted from colonic epithelial cells.