MAP4K4 and ovarian carcinoma: Among the genes identified, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4), also known as HGK (hematopoietic progenitor kinase/germinal center kinase-like kinase) [8, 9], was found to be the most significant kinase associated with metastasis in ovarian cancer.