Although IL-6 produced from ALDH− bulk tumor cells promotes ALDH+ CSCs in a paracrine fashion, downregulation of IL-6 (Fig. 4B) and upregulation of let-7a-2-3p (Fig. 5B) expression, despite to a lesser extent, were also detected in ALDH+ CSCs upon XIST KD. The gene discussed is XIST; the disease is neoplasm.