Using unbiased RNAseq analysis, we discovered that DOX-inducible XIST KD in SUM159 ALDH− bulk tumor cells and ALDH+ CSCs most significantly altered the cytokine-cytokine receptor interaction pathways in each cell population, leading to pronounced suppression of proinflammatory cytokines IL-6 and IL-8. Here, IL6 is linked to neoplasm.