In addition to suppressing the expression of tumor supportive cytokines such as IL-6, IL-8, IL1A/B, LIF, G/M-CSF, DOX-induced KD of XIST also enhances the expression of tumor suppressive cytokines such as IL-7, IL-15, IL-18, etc., suggesting that XIST functions as a master regulator of cytokine-cytokine receptor interactions, leading to increased tumor growth and CSC activity. This evidence concerns the gene XIST and neoplasm.