Downregulation of TSPAN8 was associated with IL-1β mediated inhibition of the Akt/MAPK pathway [42].The analysis of differentially expressed genes in 18 acne lesions and 18 paired normal skin samples from two datasets led to the identification of TSPAN8 as one of the few genes concurrently down-regulated in acne samples [43]. The gene discussed is AKT1; the disease is acne.